Identifying causal regulatory variants and their target genes from the majority of non-coding disease-associated genetic loci is the main challenge in post-Genome-Wide Association Studies (GWAS) functional studies.Although chromosome conformation capture (3C) and its derivative technologies have been successfully applied to nominate putative causal
Emergence and dissemination of multidrug-resistant Klebsiella pneumoniae harboring the novel tmexCD-toprJ RND efflux pump operon
The global emergence of multidrug-resistant (MDR) Klebsiella pneumoniae, particularly carbapenem-resistant K.pneumoniae (CRKP), presents a severe public health threat, limiting available treatment options.Tigecycline and eravacycline, have been considered a last-resort therapeutic against MDR Enterobacteriaceae.However, strains were resistant to th
Experimental Verification of the Performance of the Floor Cooling System in Comparison with the Ceiling Cooling System While Maintaining Thermal Comfort in the Environment
The trend of constantly increasing energy prices can be observed especially in the increased demands on the thermal insulation properties of building structures.The possibilities of reducing the energy intensity of residential buildings also include the right choice of technology for heating, cooling and hot water preparation.Different cooling syst
Predicting PTSD development with early post-trauma assessments: a proof-of-concept for a concise tree-based classification method
Background: Approximately 70% of individuals globally experience at least one traumatic event in their lifetimes, potentially leading to posttraumatic stress disorder (PTSD).Understanding the development of PTSD and devising effective prevention and treatment strategies are crucial.This proof-of-concept study aimed to design a concise tree-based ad